Article
Aβ43 is the earliest-depositing Aβ species in APP transgenic mouse brain and is converted to Aβ41 by two active domains of ACE.
The American journal of pathology - 1 Jun 2013
Zou Kun, Liu Junjun, Watanabe Atsushi, Hiraga Saeko, Liu Shuyu, Tanabe Chiaki, Maeda Tomoji, Terayama Yasuo, Takahashi Satoshi, Michikawa Makoto, Komano Hiroto
Abstract excerpt
Amyloid-β protein (Aβ) varies in length at its carboxyl terminus. The longer Aβ species, Aβ43 and Aβ42, are highly amyloidogenic and deposit more frequently than Aβ40 in the brain of Alzheimer disease (AD) patients. However, the characterization of Aβ43 deposition in the brain and the relationship between Aβ43 and Aβ42 or Aβ40 remain unclear. We provide evidence that Aβ43 deposition appears earlier than Aβ42 and...
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