Article
Beta-amyloid peptide variants in brains and cerebrospinal fluid from amyloid precursor protein (APP) transgenic mice: comparison with human Alzheimer amyloid.
The Journal of biological chemistry - 30 Sept 2011
Schieb Heinke, Kratzin Hartmut, Jahn Olaf, Möbius Wiebke, Rabe Sabine, Staufenbiel Matthias, Wiltfang Jens, Klafki Hans W
Abstract excerpt
In this study, we report a detailed analysis of the different variants of amyloid-β (Aβ) peptides in the brains and the cerebrospinal fluid from APP23 transgenic mice, expressing amyloid precursor protein with the Swedish familial Alzheimer disease mutation, at different ages. Using one- and two-dimensional gel electrophoresis, immunoblotting, and mass spectrometry, we identified the Aβ peptides Aβ(1-40),...
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