Article
Potent amyloidogenicity and pathogenicity of Aβ43.
Nature neuroscience - 3 Jul 2011
Saito Takashi, Suemoto Takahiro, Brouwers Nathalie, Sleegers Kristel, Funamoto Satoru, Mihira Naomi, Matsuba Yukio, Yamada Kazuyuki, Nilsson Per, Takano Jiro, Nishimura Masaki, Iwata Nobuhisa, Van Broeckhoven Christine, Ihara Yasuo, Saido Takaomi C
Abstract excerpt
The amyloid-β peptide Aβ42 is known to be a primary amyloidogenic and pathogenic agent in Alzheimer's disease. However, the role of Aβ43, which is found just as frequently in the brains of affected individuals, remains unresolved. We generated knock-in mice containing a pathogenic presenilin-1 R278I mutation that causes overproduction of Aβ43. Homozygosity was embryonic lethal, indicating that the mutation...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.