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Article

Abeta42-to-Abeta40- and angiotensin-converting activities in different domains of angiotensin-converting enzyme.

The Journal of biological chemistry - 13 Nov 2009

Zou Kun, Maeda Tomoji, Watanabe Atsushi, Liu Junjun, Liu Shuyu, Oba Ryutaro, Satoh Yoh-ichi, Komano Hiroto, Michikawa Makoto

Abstract excerpt

Amyloid beta-protein 1-42 (Abeta42) is believed to play a causative role in the development of Alzheimer disease (AD), although it is a minor part of Abeta. In contrast, Abeta40 is the predominant secreted form of Abeta and recent studies have suggested that Abeta40 has neuroprotective effects and inhibits amyloid deposition. We have reported that angiotensin-converting enzyme (ACE) converts Abeta42 to Abeta40,...

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Identifiers

PMID: 19773553
DOI: 10.1074/jbc.M109.011437
PMCID: PMC2797262

Genes

ACE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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