Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Systems analysis of genetic variation in MPTP neurotoxicity in mice.

Neurotoxicology - 1 Jul 2013

Jones Byron C, Miller Diane B, O'Callaghan James P, Lu Lu, Unger Erica L, Alam Gelareh, Williams Robert W

Abstract excerpt

We analyzed genetic variation in severity of neuronal damage using the known dopaminergic neurotoxicant, MPTP, as a prototypical chemical denervation agent. Male mice from ten members of the BXD family of recombinant inbred strains received 12.5 mg/kg MPTP s.c. (vs. saline) and 48 h later brains were taken for multiple related biochemical analyses. Striatal dopamine (DA) and its metabolites, DOPAC and HVA, and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dopamine
Share to Glial Fibrillary Acidic Protein
Share to Homovanillic Acid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hydroxyindoleacetic Acid

Share to Mice, Inbred DBA

Share to Serotonin

Share to Systems Biology

Share to Tyrosine 3-Monooxygenase

Source

Open in PubMed Open full text

Identifiers

PMID: 23558233
DOI: 10.1016/j.neuro.2013.03.010
PMCID: PMC4615717

Genes

GFAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Systems analysis of genetic variation in MPTP neurotoxicity in mice.PMID 23558233Read ↗

Chromosomal loci influencing the susceptibility to the parkinsonian neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.Semantic proximity Read ↗

Gene-environment interaction models to unmask susceptibility mechanisms in Parkinson's disease.Semantic proximity Read ↗

Identification of a single QTL, Mptp1, for susceptibility to MPTP-induced substantia nigra pars compacta neuron loss in mice.Semantic proximity Read ↗

Genetic dissection of strain dependent paraquat-induced neurodegeneration in the substantia nigra pars compacta.Semantic proximity Read ↗

The mouse MPTP model: gene expression changes in dopaminergic neuronsSemantic proximity Read ↗

Genetic-based, differential susceptibility to paraquat neurotoxicity in mice.Semantic proximity Read ↗

Heritability, correlations and in silico mapping of locomotor behavior and neurochemistry in inbred strains of mice.Semantic proximity Read ↗

Increased Activity of Tyrosine Hydroxylase Leads to Elevated Amphetamine Response and Markers of Oxidative Stress in Transgenic MiceSemantic proximity Read ↗

Behavioral phenotyping of the MPTP mouse model of Parkinson's disease.Semantic proximity Read ↗

Mesencephalic dopamine neuron number and tyrosine hydroxylase content: Genetic control and candidate genes.Semantic proximity Read ↗

Apoptotic factors and mitochondrial complexes assist determination of strain-specific susceptibility of mice to Parkinsonian neurotoxin MPTPSemantic proximity Read ↗

Systems genetic analysis of the effects of iron deficiency in mouse brain.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.