Article
Noncoding variation near UBE2E2 orchestrates cardiometabolic pathophenotypes through polygenic effectors.
JCI insight - 10 Dec 2024
Zhang Yang, David Natalie L, Pesaresi Tristan, Andrews Rosemary E, Kumar G V Naveen, Chen Hongyin, Qiao Wanning, Yang Jinzhao, Patel Kareena, Amorim Tania, Sharma Ankit X, Liu Silvia, Steinhauser Matthew L
Abstract excerpt
Mechanisms underpinning signals from genome-wide association studies remain poorly understood, particularly for noncoding variation and for complex diseases such as type 2 diabetes mellitus (T2D) where pathogenic mechanisms in multiple different tissues may be disease driving. One approach is to study relevant endophenotypes, a strategy we applied to the UBE2E2 locus where noncoding single nucleotide variants...
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