Article
Subcongenic analysis of tabw2 obesity QTL on mouse chromosome 6.
BMC genetics - 1 Oct 2012
Stewart Taryn P, Mao Xia, Aqqad Maha N, Uffort Deon, Dillon Kristy D, Saxton Arnold M, Kim Jung Han
Abstract excerpt
BACKGROUND: We previously established a congenic mouse strain with TALLYHO/Jng (TH) donor segment on chromosome 6 in a C57BL/6 (B6) background that harbors an obesity quantitative trait locus, tabw2. The B6.TH-tabw2 congenic mice developed increased adiposity that became exacerbated upon feeding a high fat-high sucrose (HFS) diet. To fine map the tabw2, in this study we generated and characterized subcongenic...
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