Dissection of a genetically complex cluster of growth and obesity QTLs on mouse chromosome 2 using subcongenic intercrosses.

doi:10.1007/s00335-007-9046-0

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Article

Dissection of a genetically complex cluster of growth and obesity QTLs on mouse chromosome 2 using subcongenic intercrosses.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Sept 2007

Farber Charles R, Medrano Juan F

Abstract excerpt

In a previous study we characterized the B6.CAST-(D2Mit329-D2Mit457)N(6) (B62D) congenic strain, which possesses CAST/EiJ (CAST) chromosome 2 donor alleles from 74 to 180 Mbp on a C57BL6/J (B6) background. This strain exhibited significant decreases in body weight and adiposity attributable to the weight gain 2 (Wg2) quantitative trait locus (QTL). To refine the location of Wg2, we used a two-stage genetic...

Topics

Adipose Tissue
Animals
Crosses, Genetic
Cytoskeletal Proteins
Genotype
Growth
Humans
Inbreeding
Mice
Mice, Congenic
Mice, Inbred C57BL
Mice, Obese
Multigene Family
Obesity
Quantitative Trait Loci

Source

Open in PubMed

Identifiers

PMID: 17694346
DOI: 10.1007/s00335-007-9046-0

Genes

CAST

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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