Article
Breakdown of methods for phasing and imputation in the presence of double genotype sharing.
PloS one - 1 Jan 2013
Nettelblad Carl
Abstract excerpt
In genome-wide association studies, results have been improved through imputation of a denser marker set based on reference haplotypes and phasing of the genotype data. To better handle very large sets of reference haplotypes, pre-phasing with only study individuals has been suggested. We present a possible problem which is aggravated when pre-phasing strategies are used, and suggest a modification avoiding the...
Topics
- Genome, Human
- Genotype
- HapMap Project
- Haplotypes
- Humans
- Pedigree