Article
Fast and accurate genotype imputation in genome-wide association studies through pre-phasing.
Nature genetics - 22 Jul 2012
Howie Bryan, Fuchsberger Christian, Stephens Matthew, Marchini Jonathan, Abecasis Gonçalo R
Abstract excerpt
The 1000 Genomes Project and disease-specific sequencing efforts are producing large collections of haplotypes that can be used as reference panels for genotype imputation in genome-wide association studies (GWAS). However, imputing from large reference panels with existing methods imposes a high computational burden. We introduce a strategy called 'pre-phasing' that maintains the accuracy of leading methods...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.