Article
Detection of sharing by descent, long-range phasing and haplotype imputation.
Nature genetics - 1 Sept 2008
Kong Augustine, Masson Gisli, Frigge Michael L, Gylfason Arnaldur, Zusmanovich Pasha, Thorleifsson Gudmar, Olason Pall I, Ingason Andres, Steinberg Stacy, Rafnar Thorunn, Sulem Patrick, Mouy Magali, Jonsson Frosti, Thorsteinsdottir Unnur, Gudbjartsson Daniel F, Stefansson Hreinn, Stefansson Kari
Abstract excerpt
Uncertainty about the phase of strings of SNPs creates complications in genetic analysis, although methods have been developed for phasing population-based samples. However, these methods can only phase a small number of SNPs effectively and become unreliable when applied to SNPs spanning many linkage disequilibrium (LD) blocks. Here we show how to phase more than 1,000 SNPs simultaneously for a large fraction of...
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