Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Regulation of life span by mitochondrial respiration: the HIF-1 and ROS connection.

Aging - 1 Mar 2011

Hwang Ara B, Lee Seung-Jae

Abstract excerpt

A mild reduction in mitochondrial respiration extends the life span of many species, including C. elegans. We recently showed that hypoxia-inducible factor 1 (HIF-1) is required for the acquisition of a long life span by mutants with reduced respiration in C. elegans. We suggested that increased levels of reactive oxygen species (ROS) produced in the respiration mutants increase HIF-1 activity and lead to this...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caenorhabditis elegans
Share to Caenorhabditis elegans Proteins
Share to Cell Respiration

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cellular Senescence

Share to Hypoxia-Inducible Factor 1

Share to Longevity

Share to Reactive Oxygen Species

Share to Unfolded Protein Response

Source

Open in PubMed Open full text

Identifiers

PMID: 21389351
DOI: 10.18632/aging.100292
PMCID: PMC3091523

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regulation of life span by mitochondrial respiration: the HIF-1 and ROS connection.PMID 21389351Read ↗

The HIF-1 hypoxia-inducible factor modulates lifespan in C. elegans.Semantic proximity Read ↗

Effects of the mitochondrial respiratory chain on longevity in C. elegans.Semantic proximity Read ↗

Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in Caenorhabditis elegans.Semantic proximity Read ↗

Succinate dehydrogenase upregulation destabilize complex I and limits the lifespan of gas-1 mutant.Semantic proximity Read ↗

The Good, the Bad, and the Ugly of ROS: New Insights on Aging and Aging‐Related Diseases from Eukaryotic and Prokaryotic Model OrganismsSemantic proximity Read ↗

Hypoxia-reoxygenation Extends the Lifespan of Caenorhabditis elegans via SKN-1- and DAF-16A-Dependent Stress HormesisSemantic proximity Read ↗

Taking a "good" look at free radicals in the aging process.Semantic proximity Read ↗

The paradox of mitochondrial dysfunction and extended longevity.Semantic proximity Read ↗

C. elegans miro-1 Mutation Reduces the Amount of Mitochondria and Extends Life Span.Semantic proximity Read ↗

Life-span extension from hypoxia in Caenorhabditis elegans requires both HIF-1 and DAF-16 and is antagonized by SKN-1.Semantic proximity Read ↗

Uncoupling of oxidative stress resistance and lifespan in long-lived isp-1 mitochondrial mutants in Caenorhabditis elegans.Semantic proximity Read ↗

Caenorhabditis elegans as a model for understanding ROS function in physiology and diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.