Article
WDR-23 and SKN-1/Nrf2 Coordinate with the BLI-3 Dual Oxidase in Response to Iodide-Triggered Oxidative Stress.
G3 (Bethesda, Md.) - 6 Nov 2018
Xu Zhaofa, Hu Yiman, Deng Yajun, Chen Yutao, Hua Hanqi, Huang Siyu, Nie Qian, Pan Qian, Ma Dengke K, Ma Long
Abstract excerpt
Animals utilize conserved mechanisms to regulate oxidative stress. The C. elegans SKN-1 protein is homologous to the vertebrate Nrf (NF-E2-related factor) family of cap 'n' collar (CnC) transcription factors and functions as a core regulator of xenobiotic and oxidative stress responses. The WD40 repeat-containing protein WDR-23 is a key negative regulator of SKN-1 activity. We previously found that the oxidative...
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