Article
Lack of liver X receptors leads to cell proliferation in a model of mouse dorsal prostate epithelial cell.
PloS one - 1 Jan 2013
Dufour Julie, Pommier Aurélien, Alves Georges, De Boussac Hugues, Lours-Calet Corinne, Volle David H, Lobaccaro Jean-Marc A, Baron Silvère
Abstract excerpt
Recent studies underline the implication of Liver X Receptors (LXRs) in several prostate diseases such as benign prostatic hyperplasia (BPH) and prostate cancer. In order to understand the molecular mechanisms involved, we derived epithelial cells from dorsal prostate (MPECs) of wild type (WT) or Lxrαβ-/- mice. In the WT MPECs, our results show that LXR activation reduces proliferation and correlates with the...
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