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Article

Knockdown of AKR1C3 exposes a potential epigenetic susceptibility in prostate cancer cells.

The Journal of steroid biochemistry and molecular biology - 1 Jan 2016

Doig Craig L, Battaglia Sebastiano, Khanim Farhat L, Bunce Christopher M, Campbell Moray J

Abstract excerpt

BACKGROUND: The aldo-keto reductase 1C3 (AKR1C3) has been heavily implicated in the propagation of prostate malignancy. AKR1C3 protein is elevated within prostate cancer tissue, it contributes to the formation of androgens and downstream stimulation of the androgen receptor (AR). Elevated expression of AKR1C3 is also reported in acute myeloid leukemia but the target nuclear receptors have been identified as...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26429394
DOI: 10.1016/j.jsbmb.2015.09.037
PMCID: PMC5391256

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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