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Article

Liver X Receptors Protect from Development of Prostatic Intra-Epithelial Neoplasia in Mice

9 May 2013

Abstract excerpt

LXR (Liver X Receptors) act as "sensor" proteins that regulate cholesterol uptake, storage, and efflux. LXR signaling is known to influence proliferation of different cell types including human prostatic carcinoma (PCa) cell lines. This study shows that deletion of LXR in mouse fed a high-cholesterol diet recapitulates initial steps of PCa development. Elevation of circulating cholesterol in Lxrαβ-/- double...

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PMID: 23675307
DOI: 10.1371/journal.pgen.1003483

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