Article
Targeted ablation of the histidine-rich Ca(2+)-binding protein (HRC) gene is associated with abnormal SR Ca(2+)-cycling and severe pathology under pressure-overload stress.
Basic research in cardiology - 1 May 2013
Park Chang Sik, Chen Shan, Lee Hoyong, Cha Hyeseon, Oh Jae Gyun, Hong Sunghee, Han Peidong, Ginsburg Kenneth S, Jin Sora, Park Inju, Singh Vivek P, Wang Hong-Sheng, Franzini-Armstrong Clara, Park Woo Jin, Bers Donald M, Kranias Evangelia G, Cho Chunghee, Kim Do Han
Abstract excerpt
The histidine-rich Ca(2+)-binding protein (HRC) is located in the lumen of the sarcoplasmic reticulum (SR) and exhibits high-capacity Ca(2+)-binding properties. Overexpression of HRC in the heart resulted in impaired SR Ca(2+) uptake and depressed relaxation through its interaction with SERCA2a. However, the functional significance of HRC in overall regulation of calcium cycling and contractility is not currently...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.