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Article

RyR1-mediated Ca2+-induced Ca2+ release plays a negligible role in excitation-contraction coupling of normal skeletal muscle.

Proceedings of the National Academy of Sciences of the United States of America - 26 Aug 2025

Kobayashi Takuya, Yamazawa Toshiko, Kurebayashi Nagomi, Konishi Masato, Tanihata Jun, Sugihara Masami, Miki Yoshifumi, Noguchi Satoru, Inoue Yukiko U, Inoue Takayoshi, Sakurai Takashi, Murayama Takashi

Abstract excerpt

Type 1 ryanodine receptor (RyR1) is a Ca2+ release channel in the sarcoplasmic reticulum in skeletal muscle. In excitation-contraction (E-C) coupling, RyR1 opens by depolarization of transverse tubule membrane via physical interaction with dihydropyridine receptor, which is referred to as depolarization-induced Ca2+ release (DICR). RyR1 can also be gated via Ca2+-induced Ca2+ release (CICR), in which binding of...

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PMID: 40838888
DOI: 10.1073/pnas.2500449122
PMCID: PMC12403001

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