Article
The cardiac ryanodine receptor luminal Ca2+ sensor governs Ca2+ waves, ventricular tachyarrhythmias and cardiac hypertrophy in calsequestrin-null mice.
The Biochemical journal - 1 Jul 2014
Zhang Jingqun, Chen Biyi, Zhong Xiaowei, Mi Tao, Guo Ang, Zhou Qiang, Tan Zhen, Wu Guogen, Chen Alexander W, Fill Michael, Song Long-Sheng, Chen S R Wayne
Abstract excerpt
CASQ2 (cardiac calsequestrin) is commonly believed to serve as the SR (sarcoplasmic reticulum) luminal Ca2+ sensor. Ablation of CASQ2 promotes SCWs (spontaneous Ca2+ waves) and CPVT (catecholaminergic polymorphic ventricular tachycardia) upon stress but not at rest. How SCWs and CPVT are triggered by stress in the absence of the CASQ2-based luminal Ca2+ sensor is an important unresolved question. In the present...
Topics
- Animals
- Calcium
- Calcium Signaling
- Calsequestrin
- Cardiomegaly
- Mice
- Mice, Knockout
- Mutation
- Ryanodine Receptor Calcium Release Channel
- Tachycardia, Ventricular