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Article

Effects of genetic and clinical factors on thiopurine drugs pharmacokinetics in Tunisian patients.

Pharmacogenomics - 1 Jan 2024

Chadli Zohra, Hannachi Ibtissem, Ben Belgacem Manel, Guediche Arwa, Ben Romdhane Haifa, Kerkeni Emna, Hamdi Lamia, Slama Ahlem, Chaabane Amel, Ben Fredj Nadia, Boughattas Naceur A, Safer Leila, Aouam Karim

Abstract excerpt

Aim: Thiopurine drugs are used in the treatment of various diseases including inflammatory bowel disease. Thiopurine-S-methyltransferase (TPMT) and inosine triphosphate pyrophosphatase (ITPA) are the crucial enzymes involved in thiopurines metabolism. The present study aims to investigate in Tunisian patients, the influence of genetic and nongenetic factors on thiopurine drugs pharmacokinetics.Experimental...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39382000
DOI: 10.1080/14622416.2024.2406739
PMCID: PMC11492722

Genes

TPMT
ITPA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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