Article
Assessment of thiopurine S-methyltransferase allele frequencies and phenotype-genotype concordance in a Tunisian population.
Drug metabolism and personalized therapy - 1 Sept 2025
Souissi Safa, Ben Azzouz Wissem, Ben Sassi Mouna, Ben Hammamia Syrine, Daldoul Mouna, El Jebari Hanene, Zouari Mohamed, Charfi Rim, Daghfous Riadh, Gaies Emna, Trabelsi Sameh
Abstract excerpt
OBJECTIVES: Thiopurine S-methyltransferase (TPMT) polymorphisms are associated with low or absent enzyme activity and, consequently, increased myelosuppression risk after conventional doses of azathioprine. The distribution of frequencies for deficient TPMT genotypes differs between ethnic groups. Due to limited data in Tunisia, we aimed to detect TPMT variant alleles (TPMT*2, *3B, *3C, *4) in Tunisian patients...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.