C-reactive protein triggers calcium signalling in human neutrophilic granulocytes via FcγRIIa in an allele-specific way.

doi:10.1111/sji.12049

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Article

C-reactive protein triggers calcium signalling in human neutrophilic granulocytes via FcγRIIa in an allele-specific way.

Scandinavian journal of immunology - 1 Jun 2013

Aas V, Sand K L, Asheim H-C, Benestad H B, Iversen J-G

Abstract excerpt

C-reactive protein (CRP) binds to Fcγ-receptors, FcγRIIa (CD32) with high affinity and to FcγRIa (CD64) with low affinity. The binding to CD32 has been shown to be allele specific, that is, it binds to R/R131 but not to H/H131. Little is known about the cooperation of CRP and neutrophilic granulocytes (PMNs) in inflammatory reactions. The purpose of the present study was to examine CRP signalling in human PMNs,...

Topics

Alleles
C-Reactive Protein
Calcium Signaling
Flow Cytometry
Humans
Neutrophil Activation
Neutrophils
Polymorphism, Single Nucleotide
Real-Time Polymerase Chain Reaction
Receptors, IgG
Reverse Transcriptase Polymerase Chain Reaction

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Open in PubMed

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PMID: 23551080
DOI: 10.1111/sji.12049

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