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Article

Hyper-reactive PMNs in FcgammaRIIa 131 H/H genotype periodontitis patients.

Journal of clinical periodontology - 1 Nov 2007

Nicu E A, Van der Velden U, Everts V, Van Winkelhoff A J, Roos D, Loos B G

Abstract excerpt

BACKGROUND: Receptors for the Fc part of IgG (FcgammaRIIa) on polymorphonuclear leukocytes (PMN) mediate phagocytosis and cell activation. Previous results show that one of the genetic variants of the FcgammaRIIa, the 131 H/H, is associated with more periodontal breakdown than the R/R. This may be due to hyper-reactivity of the H/H-PMNs upon interaction with bacteria. AIM: To study whether the FcgammaRIIa...

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PMID: 17877745
DOI: 10.1111/j.1600-051X.2007.01136.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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