Article
The association between a common FCGR2A polymorphism and C-reactive protein and coronary artery disease revisited.
Genetic testing and molecular biomarkers - 1 Dec 2010
Kroupis Christos, Theodorou Maria, Chaidaroglou Antigoni, Dalamaga Maria, Oliveira Samantha C, Cokkinos Dennis V, Degiannis Dimitrios, Manginas Athanassios
Abstract excerpt
INTRODUCTION: the FcγRIIa receptor is responsible for the clearance of large immune complexes and recently has been proved to be a C-reactive protein (CRP) receptor as well. A polymorphism in the corresponding FCG2RA gene resulting in an amino acid change (R131H) has been implicated, with conflicting results in the pathogenesis of various autoimmune or inflammatory disorders (e.g., atherosclerosis and coronary...
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