Article

Human Fcγ-receptors selectively respond to C-reactive protein (CRP) isoforms

2025-03-25

Abstract excerpt

The pentameric C-reactive protein (pCRP), an acute-phase protein, binds to lysophosphatidylcholine (LPC) displayed on the surface of dying cells and microorganisms to activate the complement system and to opsonize immune cells via Fcγ-receptors (FcγRs). Members of the FcγR family are characterized by the recognition of the Fc part of IgG antibodies. We utilized a mouse thymoma BW5147 reporter cell panel stably exp...

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Literature Corpus work: ae396789-ee0b-50ec-be4a-080c3d7dffa8
DOI: 10.1101/2025.03.23.644781

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