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Article

The proinflammatory effect of C-reactive protein on human endothelial cells depends on the FcγRIIa genotype.

Thrombosis research - 1 Mar 2014

Raaz-Schrauder Dorette, Ekici Arif B, Klinghammer Lutz, Stumpf Christian, Achenbach Stephan, Herrmann Martin, Reis André, Garlichs Christoph D

Abstract excerpt

INTRODUCTION: The stimulatory effects of CRP (C-reactive protein) on endothelial cells are mainly mediated via FcγRIIa. This receptor exists in two different allotypes bearing either arginine (R131) or histidine (H131) at the extracellular amino acid position 131 of the mature protein, but only FcγRIIa-R131 displays high avidity for CRP. This study investigated the role of the FcγRIIa genotype in CRP-stimulated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Human Umbilical Vein Endothelial Cells

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Share to Polymorphism, Genetic

Share to Receptors, IgG

Share to Vascular Cell Adhesion Molecule-1

Source

Identifiers

PMID: 24440139
DOI: 10.1016/j.thromres.2013.12.030

Genes

CRP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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