Article
Simple and efficient analysis of disease association with missing genotype data.
American journal of human genetics - 1 Feb 2008
Lin D Y, Hu Y, Huang B E
Abstract excerpt
Missing genotype data arise in association studies when the single-nucleotide polymorphisms (SNPs) on the genotyping platform are not assayed successfully, when the SNPs of interest are not on the platform, or when total sequence variation is determined only on a small fraction of individuals. We present a simple and flexible likelihood framework to study SNP-disease associations with such missing genotype data....
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