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Article

Asymptotically exact fit for linear mixed model in genetic association studies.

Genetics - 7 Oct 2024

Guan Yongtao, Levy Daniel

Abstract excerpt

The linear mixed model (LMM) has become a standard in genetic association studies to account for population stratification and relatedness in the samples to reduce false positives. Much recent progresses in LMM focused on approximate computations. Exact methods remained computationally demanding and without theoretical assurance. The computation is particularly challenging for multiomics studies where tens of...

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PMID: 39212459
DOI: 10.1093/genetics/iyae143
PMCID: PMC11639154

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