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Mitochondrial dysfunction in Alzheimer’s disease - a proteomics perspective

3 Apr 2021

Abstract excerpt

Mitochondrial dysfunction is involved in Alzheimer’s disease (AD) pathogenesis. Mitochondria have their own genetic material; however, most of their proteins (∼99%) are synthesized as precursors on cytosolic ribosomes, and then imported into the mitochondria. Therefore, exploring proteome changes in these organelles can yield valuable information and shed light on the molecular mechanisms underlying mitochondrial...

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PMID: 33874826
DOI: 10.1080/14789450.2021.1918550

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