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Article

Tumor heterogeneity, clonal evolution, and therapy resistance: an opportunity for multitargeting therapy.

Discovery medicine - 1 Mar 2013

Calderwood Stuart K

Abstract excerpt

Heterogeneity within the cell population is a feature of many tumors. This lack of cellular homogeneity may originate from a number of sources, including differential nutrient status due to the de novo microcirculations of tumors, to infiltration of normal cells into the tumor, and to the hierarchical natures of the cell populations from which cancers arise. Tumors are thought to arise from one or more tumor...

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Identifiers

PMID: 23545047
PMCID: PMC4083486

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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