Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Intratumoral Heterogeneity: From Diversity Comes Resistance

3 Apr 2015

Abstract excerpt

Tumors consist of a heterogeneous mixture of functionally distinct cancer cells. These functional differences can be caused by varying levels of receptor activity, differentiation, and distinct metabolic and epigenetic states. Intratumoral heterogeneity can lead to interdependence among different subpopulations of cells for sustained tumor growth. In addition, subpopulations can vary widely in their responses to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Genomics and Diagnostics
Share to Lung Cancer Treatments and Mutations
Share to Pancreatic and Hepatic Oncology Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25838394
DOI: 10.1158/1078-0432.ccr-14-1213

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Intratumoral Heterogeneity: From Diversity Comes ResistancePMID 25838394Read ↗

Intratumor Heterogeneity: The Rosetta Stone of Therapy Resistance.Semantic proximity Read ↗

Clinical implications of intratumor heterogeneity: challenges and opportunities.Semantic proximity Read ↗

Intra-tumor heterogeneity of cancer cells and its implications for cancer treatment.Semantic proximity Read ↗

Tumor heterogeneity reshapes the tumor microenvironment to influence drug resistanceSemantic proximity Read ↗

Tumor heterogeneity: preclinical models, emerging technologies, and future applicationsSemantic proximity Read ↗

From Chaos to Opportunity: Decoding Cancer Heterogeneity for Enhanced Treatment StrategiesSemantic proximity Read ↗

Understanding the Cause and Consequence of Tumor HeterogeneitySemantic proximity Read ↗

Cancer heterogeneity: implications for targeted therapeuticsSemantic proximity Read ↗

Drivers of dynamic intratumor heterogeneity and phenotypic plasticity.Semantic proximity Read ↗

Intratumoral Cellular Heterogeneity: Implications for Drug Resistance in Patients with Non-Small Cell Lung CancerSemantic proximity Read ↗

Tumor heterogeneity: Causes and consequencesSemantic proximity Read ↗

Tumor heterogeneity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.