Article
Intratumoral heterogeneity and consequences for targeted therapies.
Bulletin du cancer - 1 Jan 2015
Turtoi Andrei, Blomme Arnaud, Castronovo Vincent
Abstract excerpt
According to the clonal model and Darwinian evolution, cancer cell evolves through new mutations helping it to proliferate, migrate, invade and metastasize. Recent genetic studies have clearly shown that tumors, when diagnosed, consist of a large number of mutations distributed in different cells. This heterogeneity translates in substantial genetic plasticity enabling cancer cells to adapt to any hostile...
Topics
- Adaptation, Physiological
- Cell Survival
- Evolution, Molecular
- Humans
- Molecular Targeted Therapy
- Mutation
- Neoplasms
- Phenotype
- Proteomics
- Receptor Protein-Tyrosine Kinases
- Receptors, Growth Factor