Article
Clinical implications of intratumor heterogeneity: challenges and opportunities.
Journal of molecular medicine (Berlin, Germany) - 1 Feb 2020
Ramón Y Cajal Santiago, Sesé Marta, Capdevila Claudia, Aasen Trond, De Mattos-Arruda Leticia, Diaz-Cano Salvador J, Hernández-Losa Javier, Castellví Josep
Abstract excerpt
In this review, we highlight the role of intratumoral heterogeneity, focusing on the clinical and biological ramifications this phenomenon poses. Intratumoral heterogeneity arises through complex genetic, epigenetic, and protein modifications that drive phenotypic selection in response to environmental pressures. Functionally, heterogeneity provides tumors with significant adaptability. This ranges from mutual...
Topics
- Animals
- Epigenesis, Genetic
- Genetic Heterogeneity
- Humans
- Neoplasms
- Phenotype
- Tumor Microenvironment