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Article

Intratumor heterogeneity: seeing the wood for the trees.

Science translational medicine - 28 Mar 2012

Yap Timothy A, Gerlinger Marco, Futreal P Andrew, Pusztai Lajos, Swanton Charles

Abstract excerpt

Most advanced solid tumors remain incurable, with resistance to chemotherapeutics and targeted therapies a common cause of poor clinical outcome. Intratumor heterogeneity may contribute to this failure by initiating phenotypic diversity enabling drug resistance to emerge and by introducing tumor sampling bias. Envisaging tumor growth as a Darwinian tree with the trunk representing ubiquitous mutations and the...

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Identifiers

PMID: 22461637
DOI: 10.1126/scitranslmed.3003854

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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