Article
Novel IL-6 haplotypes and disease association.
Genes and immunity - 1 Jun 2005
Fife M S, Ogilvie E M, Kelberman D, Samuel J, Gutierrez A, Humphries S E, Woo P
Abstract excerpt
Interleukin-6 (IL-6) is a pleiotropic cytokine crucial in both adaptive and innate immunity. Numerous genetic studies have shown association with variants of this gene in a multitude of diseases and phenotypes. Most tests of association have focused on a limited set of promoter polymorphisms, in particular, the -174G>C; however, there are many inconsistencies within and between these studies. We propose that...
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