Article
The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis.
The Journal of clinical investigation - 1 Oct 1998
Fishman D, Faulds G, Jeffery R, Mohamed-Ali V, Yudkin J S, Humphries S, Woo P
Abstract excerpt
During active disease, patients with systemic-onset juvenile chronic arthritis (S-JCA) demonstrate a rise and fall in serum interleukin-6 (IL-6) that parallels the classic quotidian fever. To investigate the possibility that this cytokine profile results from a difference in the control of IL-6 e...
Topics
- Adolescent
- Adult
- Age of Onset
- Aged
- Arthritis, Juvenile
- Base Sequence
- Child
- DNA Primers
- Female
- Gene Expression Regulation
- Gene Frequency
- Genotype
- HeLa Cells
- Humans
- Interleukin-6
- London