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Article

Steering directed protein evolution: strategies to manage combinatorial complexity of mutant libraries.

Environmental microbiology - 1 Nov 2007

Wong Tuck Seng, Roccatano Danilo, Schwaneberg Ulrich

Abstract excerpt

How to explore protein sequence space efficiently and how to generate high-quality mutant libraries that allow to identify improved variants with current screening technologies are key questions for any directed protein evolution experiment. High-quality mutant libraries can be generated through improved random mutagenesis methodologies and by restricting diversity generation through computational methods to...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 17922750
DOI: 10.1111/j.1462-2920.2007.01411.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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