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Article

Protein Engineering by Combined Computational and In Vitro Evolution Approaches.

Trends in biochemical sciences - 1 May 2016

Rosenfeld Lior, Heyne Michael, Shifman Julia M, Papo Niv

Abstract excerpt

Two alternative strategies are commonly used to study protein-protein interactions (PPIs) and to engineer protein-based inhibitors. In one approach, binders are selected experimentally from combinatorial libraries of protein mutants that are displayed on a cell surface. In the other approach, computational modeling is used to explore an astronomically large number of protein sequences to select a small number of...

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Identifiers

PMID: 27061494
DOI: 10.1016/j.tibs.2016.03.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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