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Article

Updated field synopsis and systematic meta-analyses of genetic association studies in cutaneous melanoma: the MelGene database.

The Journal of investigative dermatology - 1 Apr 2015

Antonopoulou Kyriaki, Stefanaki Irene, Lill Christina M, Chatzinasiou Foteini, Kypreou Katerina P, Karagianni Fani, Athanasiadis Emmanouil, Spyrou George M, Ioannidis John P A, Bertram Lars, Evangelou Evangelos, Stratigos Alexander J

Abstract excerpt

We updated a field synopsis of genetic associations of cutaneous melanoma (CM) by systematically retrieving and combining data from all studies in the field published as of August 31, 2013. Data were available from 197 studies, which included 83,343 CM cases and 187,809 controls and reported on 1,126 polymorphisms in 289 different genes. Random-effects meta-analyses of 81 eligible polymorphisms evaluated in >4...

Topics

Chromosome Mapping
Databases, Genetic
Gene Expression Regulation, Neoplastic
Genetic Predisposition to Disease
Genetic Variation
Genome-Wide Association Study
Germ-Line Mutation
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Linkage Disequilibrium

Melanoma

Odds Ratio

Polymorphism, Single Nucleotide

Skin Neoplasms

Melanoma, Cutaneous Malignant

Source

Identifiers

PMID: 25407435
DOI: 10.1038/jid.2014.491

Genes

ARNT
ATM
CASP8
CCND1
CDK10
FTO
MITF
MTAP
TYR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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