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Article

Inherited variations in human pigmentation-related genes modulate cutaneous melanoma risk and clinicopathological features in Brazilian population.

Scientific reports - 22 Jul 2020

Lourenço Gustavo Jacob, Oliveira Cristiane, Carvalho Benilton Sá, Torricelli Caroline, Silva Janet Keller, Gomez Gabriela Vilas Bôas, Rinck-Junior José Augusto, Oliveira Wesley Lima, Vazquez Vinicius Lima, Serrano Sergio Vicente, Moraes Aparecida Machado, Lima Carmen Silvia Passos

Abstract excerpt

Ultraviolet light exposure and cutaneous pigmentation are important host risk factors for cutaneous melanoma (CM), and it is well known that inherited ability to produce melanin varies in humans. The study aimed to identify single-nucleotide variants (SNVs) on pigmentation-related genes with importance in risk and clinicopathological aspects of CM. The study was conducted in two stages. In stage 1, 103 CM...

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Identifiers

PMID: 32699307
DOI: 10.1038/s41598-020-68945-9
PMCID: PMC7376158

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