Article
Novel regulators and molecular mechanisms of p53R2 and its disease relevance.
Biochimie - 1 Apr 2016
Cho E C, Yen Y
Abstract excerpt
p53R2 is a p53-inducible human ribonucleotide reductase subunit involved in critical cellular mechanisms, such as DNA repair, cell cycle arrest, and mitochondrial homeostasis. Molecular investigations and animal studies have revealed functional regulations of p53R2 and its disease relevance. The relationship between p53R2 expression and disease progression in different cancers has been evaluated, and researchers...
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