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Article

Proapoptotic p53-interacting protein 53BP2 is induced by UV irradiation but suppressed by p53.

Molecular and cellular biology - 1 Nov 2000

Lopez C D, Ao Y, Rohde L H, Perez T D, O'Connor D J, Lu X, Ford J M, Naumovski L

Abstract excerpt

p53 is an important mediator of the cellular stress response with roles in cell cycle control, DNA repair, and apoptosis. 53BP2, a p53-interacting protein, enhances p53 transactivation, impedes cell cycle progression, and promotes apoptosis through unknown mechanisms. We now demonstrate that endogenous 53BP2 levels increase following UV irradiation induced DNA damage in a p53-independent manner. In contrast, we...

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Identifiers

PMID: 11027272
DOI: 10.1128/MCB.20.21.8018-8025.2000
PMCID: PMC86412

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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