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p53R2 Inhibits the Proliferation of Human Cancer Cells in Association with Cell-Cycle Arrest

7 Jan 2011

Abstract excerpt

Deregulation of the expression of p53R2, a p53-inducible homologue of the R2 subunit of ribonucleotide reductase, has been found in various human cancer tissues; however, the roles p53R2 plays in cancer progression and malignancy remain controversial. In the present study, we examined changes in gene expression profiles associated with p53R2 in cancer cells, using the analysis of cDNA microarray. Gene set...

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PMID: 21216934
DOI: 10.1158/1535-7163.mct-10-0728

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