Genome-wide association studies of the PR interval in African Americans.

doi:10.1371/journal.pgen.1001304

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Article

Genome-wide association studies of the PR interval in African Americans.

PLoS genetics - 10 Feb 2011

Smith J Gustav, Magnani Jared W, Palmer Cameron, Meng Yan A, Soliman Elsayed Z, Musani Solomon K, Kerr Kathleen F, Schnabel Renate B, Lubitz Steven A, Sotoodehnia Nona, Redline Susan, Pfeufer Arne, Müller Martina, Evans Daniel S, Nalls Michael A, Liu Yongmei, Newman Anne B, Zonderman Alan B, Evans Michele K, Deo Rajat, Ellinor Patrick T, Paltoo Dina N, Newton-Cheh Christopher, Benjamin Emelia J, Mehra Reena, Alonso Alvaro, Heckbert Susan R, Fox Ervin R

Abstract excerpt

The PR interval on the electrocardiogram reflects atrial and atrioventricular nodal conduction time. The PR interval is heritable, provides important information about arrhythmia risk, and has been suggested to differ among human races. Genome-wide association (GWA) studies have identified common genetic determinants of the PR interval in individuals of European and Asian ancestry, but there is a general paucity...

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PMID: 21347284
DOI: 10.1371/journal.pgen.1001304
PMCID: PMC3037415

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MEIS1
TBX5

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