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Article

Polymorphic variants in PTGS2 and prostate cancer risk: results from two large nested case-control studies.

Carcinogenesis - 1 Mar 2008

Danforth Kim N, Hayes Richard B, Rodriguez Carmen, Yu Kai, Sakoda Lori C, Huang Wen-Yi, Chen Bingshu E, Chen Jinbo, Andriole Gerald L, Calle Eugenia E, Jacobs Eric J, Chu Lisa W, Figueroa Jonine D, Yeager Meredith, Platz Elizabeth A, Michaud Dominique S, Chanock Stephen J, Thun Michael J, Hsing Ann W

Abstract excerpt

Chronic inflammation has been hypothesized to increase prostate cancer risk. Prostaglandin-endoperoxide synthase 2 (PTGS2) encodes the proinflammatory cyclooxygenase 2 enzyme believed to be the rate-limiting step in the synthesis of prostaglandins, important mediators of inflammation. We investig...

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Source

Identifiers

PMID: 17999989
DOI: 10.1093/carcin/bgm253

Genes

PTGS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17999989-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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