Effect of COX2 -765G>C and c.3618A>G polymorphisms on the risk and survival of sporadic colorectal cancer.

doi:10.1007/s10552-009-9368-1

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Article

Effect of COX2 -765G>C and c.3618A>G polymorphisms on the risk and survival of sporadic colorectal cancer.

Cancer causes & control : CCC - 1 Oct 2009

Iglesias Daniel, Nejda Nargisse, Azcoita Mariano Moreno, Schwartz Simó, González-Aguilera Juan J, Fernández-Peralta Antonia M

Abstract excerpt

BACKGROUND: The COX2 gene (also known as PTGS2) encodes one of the essential cyclooxygenases for the prostanoid synthesis, and its expression is tightly regulated at both transcriptional and posttranscriptional levels. COX2 overexpression has been detected in up to 90% of colon carcinomas, and its downregulation inhibits polyp formation. Several polymorphisms located in both 5'- and 3'- flanking regions of COX2...

Topics

Adenocarcinoma
Adult
Aged
Aged, 80 and over
Base Sequence
Case-Control Studies
Colorectal Neoplasms
Cyclooxygenase 2
Female
Genetic Predisposition to Disease
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Polymorphism, Single Nucleotide

Promoter Regions, Genetic

Risk Factors

Survival Analysis

Source

Open in PubMed

Identifiers

PMID: 19468846
DOI: 10.1007/s10552-009-9368-1

Genes

PTGS2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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Effect of COX2 -765G>C and c.3618A>G polymorphisms on the risk and survival of sporadic colorectal cancer.PMID 19468846Read ↗

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