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Article

Genetic Variations in Prostaglandin E2 Pathway Identified as Susceptibility Biomarkers for Gastric Cancer in an Intermediate Risk European Country.

International journal of molecular sciences - 11 Jan 2021

Lopes Catarina, Pereira Carina, Farinha Mónica, Medeiros Rui, Dinis-Ribeiro Mário

Abstract excerpt

The cyclooxygenase-2 (COX-2)/prostaglandin E2 (PGE2) pathway exerts deleterious pleiotropic effects in inflammation-induced gastric carcinogenesis. We aimed to assess the association of genetic variants in prostaglandin-endoperoxide synthase 2 (PTGS2), ATP binding cassette subfamily C member 4 (ABCC4), hydroxyprostaglandin dehydrogenase 15-(NAD) (HPGD), and solute carrier organic anion transporter family member...

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Identifiers

PMID: 33440718
DOI: 10.3390/ijms22020648
PMCID: PMC7827533

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