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Article

Liposomic lubricants suppress acute inflammatory gene regulation in the joint in vivo

10 Apr 2025

Abstract excerpt

Osteoarthritis (OA) is a widespread, debilitating joint disease associated with articular cartilage degradation. It is driven via mechano-inflammatory pathways, whereby catabolic genes in the cartilage-embedded chondrocytes are presumed up-regulated due to increased shear stress arising from friction at the cartilage surface as joints articulate. The enhanced expression of these cartilage-degrading and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 40220945
DOI: 10.1016/j.actbio.2025.04.022

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