Article
Structural Basis of the Differential Function of the Two C. elegans Atg8 Homologs, LGG-1 and LGG-2, in Autophagy.
Molecular cell - 17 Dec 2015
Wu Fan, Watanabe Yasunori, Guo Xiang-Yang, Qi Xin, Wang Peng, Zhao Hong-Yu, Wang Zheng, Fujioka Yuko, Zhang Hui, Ren Jin-Qi, Fang Tian-Cheng, Shen Yu-Xian, Feng Wei, Hu Jun-Jie, Noda Nobuo N, Zhang Hong
Abstract excerpt
Multicellular organisms have multiple homologs of the yeast ATG8 gene, but the differential roles of these homologs in autophagy during development remain largely unknown. Here we investigated structure/function relationships in the two C. elegans Atg8 homologs, LGG-1 and LGG-2. lgg-1 is essential for degradation of protein aggregates, while lgg-2 has cargo-specific and developmental-stage-specific roles in...
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