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Article

O-GlcNAc-modification of SNAP-29 regulates autophagosome maturation.

Nature cell biology - 1 Dec 2014

Guo Bin, Liang Qianqian, Li Lin, Hu Zhe, Wu Fan, Zhang Peipei, Ma Yongfen, Zhao Bin, Kovács Attila L, Zhang Zhiyuan, Feng Du, Chen She, Zhang Hong

Abstract excerpt

The mechanism by which nutrient status regulates the fusion of autophagosomes with endosomes/lysosomes is poorly understood. Here, we report that O-linked β-N-acetylglucosamine (O-GlcNAc) transferase (OGT) mediates O-GlcNAcylation of the SNARE protein SNAP-29 and regulates autophagy in a nutrient-dependent manner. In mammalian cells, OGT knockdown, or mutating the O-GlcNAc sites in SNAP-29, promotes the formation...

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Identifiers

PMID: 25419848
DOI: 10.1038/ncb3066

Genes

OGT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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